Stand Up to Cancer 2010

Cancer survivors, with Christina Applegate, Maura Tierney, Michael C. Hall, Elizabeth Edwards, Ethan Zohn of 'Survivor,' Sofia Vergara and cyclist Lance Armstrong, will also stand up, and Michael Douglas, who is battle throat cancer, will come out.

It's the second edition of the telethon as the first raised more than $100 million for cancer research in 2008. The aim of the event is to raise money for the American Association for Cancer Research to speed up original cancer research.

George Clooney, Gwyneth Paltrow, Will Smith, Denzel Washington, Renee Zellweger, Ryan Seacrest, Seth Rogen, Kyra Sedgwick, Jay Leno, Jane Lynch and the Simpsons are just a small sample of the celebs who will appear. Musicians including Stevie Wonder, Lady Antebellum, Leona Lewis, Billie Joe Armstrong of Green Day and Neil Diamond are among those who will perform.

Dozens of actors, musicians and athletes will take part in the 'Stand Up To Cancer 2010' telethon, set to air Fri. Sept. 10 at 8PM ET at the same time on ABC, CBS, FOX, NBC, HBO, Showtime, and other outlets and stream on multiple internet portals.

Network news anchors Diane Sawyer (ABC), Brian Williams (NBC) and Katie Couric (CBS) will host the events. Couric, whose husband Jay Monahan died of colon cancer in 1998, is a founding member of the Stand Up To Cancer team.

Cat Deeley of FOX's 'So You Think You Can Dance' will host a pre-show starting 7:30PM ET as the celebrity phone bank opens and there will be half-hour "after hours'' show featuring musical guests Fitz and the Tantrums, Orianthi, Natasha Bedingfield and Heart. Both the pre-show and after-show will be available online.